Investigative protocols assist you with the interpretation of some common laboratory result abnormalities and the investigation of some selected clinical conditions. They are derived from a set of protocols originally produced by Dr Noel Walmsley. Some of these have now been updated, and further protocols have been added with time - Dr John Roberts.

The range of investigative protocols cover conditions associated with:
Clinical Conditions
Abbreviation IP Title
Female Evaluation of ?androgen excess and/or hirsutism (female).
Female 1 Evaluation of female infertility
Female 2 Evaluation of irregular periods.
Female 4 Hormonal changes during menstrual cycle
HEP B 2 Hepatitis B immune status
Pot High 1 Causes of hyperkalaemia - K+ > 5.0
Prl High 1 Causes of hyperprolactinaemia (prolactin > 700 mlU/L)
Coagulation Tests
Abbreviation IP Title
Platelet 1 Platelet function analyser
Thrombosis 1 Risk factors for venous thromboembolism
vWF1 von Willebrand disease
Drug Screen Interpretation
Abbreviation IP Title
Buprenorphine Evaluation of Buprenorphine results.
Methadone Metabolite Evaluation of EDDP (methadone metabolite) results
THC Evaluation of Δ9-tetrahydrocannabinol (THC) results
UDS1 Urine drug screening
UDS Amph Evaluation of sympathomimetic amine results
UDS Barb Evaluation of barbiturate results
UDS Benzo Evaluation of benzodiazepine results
UDS Cocaine Evaluation of cocaine results
UDS Opiate Evaluation of opiate results
UDS TLC Thin layer chromatography
Endocrine Tests
Abbreviation IP Title
TSH High 1 Evaluation of an elevated serum TSH (> 4.0 mU/L)
TSH Low 1 Evaluation of a subnormal serum TSH (< 0.2 mU/L)
General Biochemistry
Abbreviation IP Title
Allergen specific IgE Specific IgE levels conferring very high risk.
Hypocal Evaluation of hypocalcaemia - Ca2+ < 2.2
Bicarb Low Causes of low plasma HCO3 - HCO3 < 18
CK High Causes of an elevated CK - M > 200 F > 140
Calcium High 1 Causes of hypercalcaemia - Ca2+ > 2.6
Calcium High 2 Evaluation of hypercalcaemia - Ca2+ > 2.6
Globulin High Evaluation of hyperglobulinaemia - globulins > 44
Glucose Low Evaluation of hypoglycaemia (plasma glucose < 2.8 mmol/L)
LDI Evaluation of lactate dehydrogenase isoenzymes (LDI)
MI Change Cardiac enzyme changes during myocardial infarction
Mag Low Causes of hypomagnesaemia (Mg < 0.7 mmol/L)
Phos High Causes of hyperphosphataemia - PO42+ > 1.8
Phos Low Causes of hypophosphataemia (mild: 0.5~0.65 mmol/L; severe: < 0.4 mmol/L)
Polyuria Evaluation of polyuria (urine vol > 3 L/24 hours)
Pot High 2 Evaluation of hyperkalaemia - K+ > 5.0
Pot High 1 Causes of hyperkalaemia - K+ > 5.0
Pot Low 1 Causes of hypokalaemia - K+ < 3.0
Pot Low 2 Evaluation of hypokalaemia - K+ < 3.0
Sodium Low Causes of hyponatraemia - Na+ < 130
Urate High Evaluation of hyperuricaemia - urate > 0.45 (male) urate > 0.40 (female)
Immunology
Abbreviation IP Title
Band 1 Evaluation of plasma cell dyscrasias
Band 2 Evaluation of IgM plasma cell dyscrasias
Coeliac 1 Coeliac disease investigation
DNA/ENA Anti-dsDNA and anti-ENA antibodies
IgA Low 1 Evaluation of selective IgA deficiency
Liver Function Test
Abbreviation IP Title
ALP High 1 Evaluation of an isolated serum alkaline phosphatase (ALP) elevation - ALP > 180
ALP High 2 Serum alkaline phosphatase (ALP) elevation - ALP > 180
ALP High 3 Evaluation of an isolated serum alkaline phosphatase (ALP) elevation ? growth related - Age < 19 yrs, 300 < ALP < 400
ALP High 4 Serum alkaline phosphatase (ALP) elevation ? growth related - age < 19 yrs, 300 < ALP < 400
ALP High 5 Marked serum alkaline phosphatase (ALP) elevation - ALP > 700, age < 5 yrs
GGT High 1 Causes of an elevated serum gamma glutamyl transferase (GGT) (GGT > 100 U/L)
LD High 1 Evaluation of an elevated serum LD (> 300 U/L)
LFT1 Evaluation of a moderate elevation of aminotransferase levels (AST; ALT) - bili < 50, 45 < ALT < 150
LFT2 Predominant hepatocellular pathology (ALT or AST > 150 U/L; ALP < 200 U/L)
LFT3 Evaluation of a LFT pattern not typical of liver disease (elevated LD, AST >> ALT)
LFT4 Causes of isolated hyperbilirubinaemia - bili > 25, other LFTs normal
LFT5 Evaluation of isolated hyperbilirubinaemia (bilirubin > 30 mmol/L; other LFTs normal)
LFT6 Evaluation of jaundice (ALT < 400 U/L; ALP > 350 U/L)
LFT7 Evaluation of jaundice (ALT > 300 U/L; ALP < 350 U/L)
LFT8 Evaluation of localised cholestasis (ALP > 180 U/L; ALT < 150 U/L; GGT > 100 U/L; bilirubin < 50 umol/L)
LFT9 Evaluation of mixed hepatocellular and cholestatic disease (ALP > 180; GGT > 65; ALT or AST > 150)
Microbiology & Patient Notes
Abbreviation IP Title
Carbapenem Resistant Enterobacteriaceae A family of gram-negative bacilli that occur naturally in the gastro-intestinal tract.
Chikungunya virus & Zika viruses Arthropod-borne viruses (arboviruses) transmitted principally by mosquitoes.
Haematuria 1 Causes of isolated microscopic haematuria
Occult Blood 1 Faecal occult blood
Pleural effusions Pleural effusions - Aetiology, Classification and Tests.
Q Fever Zoonotic disease caused by Coxiella burnetti.
What is Barmah Forest Virus? Description of symptom treatment and prevention of Barmah Forest virus.
What is Blastocystosis? What is Blastocystosis?
What is Cryptosporidiosis? What is Cryptosporidiosis?
What is Giardiasis? What is Giardiasis?
What is Listeriosis? What is Listeriosis?
What is Parvovirus? What is Parvovirus?
What is Ross River Virus? What is Ross River virus?
Serology
Abbreviation IP Title
Chronic Hepatitis B Laboratory testing and treatment.
Hep A 1 Serological events in acute (self-limiting) hepatitis A infection relative to alanine aminotransferese (ALT) peak
Hep B 1 Serological events in acute (self-limiting) hepatitis B infection relative to Alanine Aminotransferese (ALT) peak
Pertussis 1 Treatment of Bordetella pertussis
Warfarin Management
Abbreviation IP Title
Warfarin 1 Range of International Normalised Ratio (INR) recommended for specific applications of warfarin therapy
Warfarin 2 Guidelines for the management of an elevated INR, with or without bleeding
Warfarin 3 Risk factors for bleeding complications of Warfarin therapy